Nucleosides and Analogues
Medchemexpress LLC Ribavirin | 36791-04-5 | 100.0% | 244.20 | 500 MG
Ribavirin (ICN-1229) is an antiviral agent effective against a broad spectrum of viruses, including HCV, HIVl, and RSV. It also exhibits anti-orthopoxvirus and anti-variola activities.
- Effective against a broad spectrum of viruses
- Exhibits anti-orthopoxvirus and anti-variola activities
- Induces reduction of NO2 levels in LPS-stimulated microglia
- Active against DENV
- Significantly lowers ALT, AST activities and bilirubin levels in vivo
- Reduces expression of TGF-β and Bax
Apexbio Technology LLC 5-BrdU(Synonyms: Bromodeoxyuridine, BrdU, 5-Bromo-2'-deoxyuridine, 5-Bromodeoxyuridine), 1g, CAS: 59-14-3.
5-Bromo-2 -deoxyuridine (5-BrdU CAS 59-14-3) is a thymidine analog that integrates into DNA during S-phase of cell division Its incorporation facilitates immunodetection via specific monoclonal or polyclonal antibodies In vitro studies show that early application of 5-BrdU to Nicotiana glauca pith explants inhibits cellular proliferation an effect reversed by addition of thymidine or deoxycytidine In vivo BrdU immunostaining identifies proliferating neuronal cells in mouse central nervous system tissues paralleling earlier thymidine labeling studies Thus 5-BrdU serves as a molecular tool for analyzing cell cycle progression and neurogenesis in biomedical research
Apexbio Technology LLC GTP-Binding Protein Fragment, G alpha 25mg
GTP-Binding Protein Fragment G alpha is a peptide fragment derived from the amino-terminal region of the alpha subunit of GTP-binding proteins It is designed to aid in elucidating the mechanisms of membrane association and -subunit interactions in cell signaling pathways GTP-Binding Protein Fragment G alpha exerts its biological activity by retaining membrane-binding properties independent of the nucleotide-binding state anchoring the protein to the cytoplasmic membrane surface This peptide fragment serves as an experimental tool to study membrane-association mechanisms and signal transduction pathways in biochemical and biomedical research Based on these properties GTP-Binding Protein Fragment G alpha holds research potential in investigating the molecular basis of G protein-mediated signal transduction and protein-membrane interactions
Apexbio Technology LLC 2'-O-Methyl-2-Amino-ATP 50ul (100 mM)
2p-O-Methyl-2-Amino-ATP is a modified nucleoside triphosphate incorporating methylation at the ribose 2 -hydroxyl group and an amino substitution at the 2 position of the adenine base It is designed to alter nucleotide biochemical properties impacting RNA stability and structure upon enzymatic incorporation In in vitro transcription assays 2p-O-Methyl-2-Amino-ATP demonstrates an ability to increase RNA resistance to exonuclease-mediated degradation and induce altered RNA secondary structures Based on these properties 2p-O-Methyl-2-Amino-ATP holds research potential in studies of RNA folding dynamics stability assays RNA-protein interactions and analyses involving chemically modified RNA in biomedical research
![Alkali Scientific AMP [Adenosine 5 Monophosphate, Free Acid], 1 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000660300.jpg-250.jpg)
Alkali Scientific AMP [Adenosine 5 Monophosphate, Free Acid], 1 G
Adenosine 5' Monophosphate (AMP), Free Acid, is a nucleotide reagent commonly used in laboratory applications such as enzyme assays, molecular biology, and biochemistry. AMP serves as an essential building block for RNA synthesis and plays a key role in energy transfer within cells as part of the ATP/ADP cycle. This 1g sample is suitable for use in various assays, including kinase activity assays, cell signaling studies, and the synthesis of RNA oligonucleotides. AMP is also involved in ATP-dependent processes and is widely used in research on cellular metabolism, signal transduction, and DNA/RNA synthesis in biochemical studies.
Medchemexpress LLC Guanosine 5'-diphosphate sodium | 43139-22-6 | 99.9% | 465.18 | 500 MG
Guanosine 5'-diphosphate sodium is a nucleoside diphosphate known for activating adenosine 5'-triphosphate-sensitive K+ channels. It acts as an iron mobilizer by forming a complex with hepcidin, which inhibits the hepcidin-ferroportin (FPN) interaction and modulates the IL-6/Stat-3 pathway. This compound has been shown to ameliorate Turpentine-induced anemia of inflammation (AI) in mice, especially when combined with FeSO4, highlighting its utility in AI research.
- Activates ATP-sensitive K+ channels.
- Mobilizes iron by inhibiting hepcidin-FPN interaction.
- Modulates IL-6/Stat-3 pathway.
- Ameliorates anemia of inflammation (AI).
- Increases iron absorption and FPN levels in liver, spleen, and enterocytes.
- Reduces iron storage ferritin and Stat-3 phosphorylation.
- Decreases Hamp mRNA and hepcidin expression.
eMolecules 3'-DEOXYCYTIDINE | 7057-33-2 | MFCD00079144 | 1g
AstaTech | 3'-DEOXYCYTIDINE | 1g | 290666855 | F11003 | 95.000 | 7057-33-2 | MFCD00079144 | 227.220 | C9H13N3O4
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Medchemexpress LLC 2'-Deoxyguanosine | 961-07-9 | MFCD00006540 | >=98% | 268.22 | 1 ML
2'-Deoxyguanosine (Deoxyguanosine) is a purine nucleoside with a variety of biological activities. It can induce DNA division in mouse thymus cells and is a potent cell division inhibitor in plant cells.
- Purine nucleoside
- Induces DNA division in mouse thymus cells
- Potent cell division inhibitor in plant cells
- Inhibits clonal growth of HL-60 and K562 leukemia cells
Medchemexpress LLC 2'-Deoxyadenosine monohydrate | 16373-93-6 | 99.9% | 269.26 | 1 ML
2'-Deoxyadenosine monohydrate is an adenine nucleoside used in research that demonstrates various biological activities including the inhibition of glucose-stimulated insulin release and islet cAMP accumulation. It also activates caspase-3, promotes apoptosis, inhibits SAHH activity, and has an anticancer effect on colon cancer by inhibiting cell growth.
- Inhibits glucose-stimulated insulin release.
- Inhibits glucose-stimulated increases in islet cyclic AMP (cAMP) accumulation.
- Activates caspase-3 and promotes apoptosis.
- Inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH).
- Inhibits the growth of various cells.
- Has an anticancer effect on colon cancer.
Selleck Chemical LLC Uridine 5-diphosphoglucose disodium salt S3216-25mg
Uridine-5 -diphosphoglucose (UDPG UDP-Glc UDP-D-Glucose UDP- -D-Glucose) activates the P2Y(14) receptor a neuroimmune system GPCR Uridine-5 -diphosphoglucose is the precursor of glucose-containing oligosaccharides polysaccharides glycoproteins and glycolipids in animal tissues and in some microorganisms
Medchemexpress LLC 2'-Deoxyuridine 5'-monophosphate disodium | 42155-08-8 | CB9482517 | 100.0% | 352.15 | 250 MG
2'-Deoxyuridine 5'-monophosphate disodium (dUMP disodium) is a deoxynucleotide and an endogenous metabolite. It is reductively methylated to dTMP, a nucleotide essential for DNA synthesis. This compound exhibits anti-bacterial activity against *Helicobacter pylori* by inhibiting HpThyX enzyme activities. It is provided as a solid, white to off-white in color, and is intended for research use only.
- Deoxynucleotide
- Reductively methylated to dTMP
- Required for DNA synthesis
- Exhibits anti-bacterial activity
- Solid appearance
- White to off-white color
- Endogenous metabolite
- For research use only
Apexbio Technology LLC Adenosine Kinase Inhibitor (hydrate) 1mg
Adenosine Kinase Inhibitor (hydrate) is a small-molecule inhibitor targeting adenosine kinase It is designed to inhibit adenosine kinase thereby regulating intracellular adenosine metabolism Adenosine Kinase Inhibitor (hydrate) exerts its biological activity primarily through selective enzyme inhibition In cell-free conditions Adenosine Kinase Inhibitor (hydrate) demonstrates potent inhibitory activity with an IC50 value of approximately 1 7 nM Based on these pharmacological properties Adenosine Kinase Inhibitor (hydrate) holds research potential in investigating pain perception mechanisms and inflammation modulation through adenosine signaling pathways